Chromatin BioScience Ltd

Chromatin Bioscience is a biotechnology company focused on the design and development of synthetic promoters for gene and cell therapies and bioprocessing. Our innovative platform enables precise, cell-type selective, and durable gene expression, which is key to advancing the next generation of gene therapies. Chromatin’s synthetic promoters have been integral in the development of therapies for a range of diseases, enhancing both safety and efficacy. 

We have developed a platform of algorithms and know-how that is engineered to run meta-analyses on diverse functional genomics datasets and enable us to:

Isolate Cell-Selective and Conditional Enhancers:

Identify short gene regulatory motifs in the genome that are active in specific cell types or active under specific environmental conditions

To generate libraries of small genetic parts that can control gene expression in specific cell types or in response to different types of stimuli

Create Novel Synthetic Gene Expression Vectors:

Engineer genetic circuitry from these motifs to create constructs that allow cell-type selective, controllable gene expression

By combining multiple genetic parts from our library to construct synthetic promoters and expression vectors that meet a target activity profile

Work to Client Demand for Custom Gene Control:

Rationally-designed to confer more effective and tighter control of gene payload expression to a precise specification

Unique sequence combinations, not found naturally, and so can be patented and used to create an effective IP estate to protect a product or process

• Genetics/Genomics
• Stem Cells/Regenerative Medicine